Showing posts with label cancer. Show all posts
Showing posts with label cancer. Show all posts

Monday, 24 September 2012

Of book clubs and Fifty Shades of Grey: readers are horses and EL James holds the reins



It happened again the other night, this time at book club meeting. The book was pretty wonderful, but I was there as much to see my friends as to discuss the book (the way I imagine most book clubs function), and we were also celebrating the hostess’s having been given the green light to go back to work after a year off to deal with round two of breast cancer. So a lovely prosecco was the preferred initial libation, and it lubricated our group in a most satisfactory way.

The book under discussion that evening was Half of a yellow sun by Chimamanda Ngozi Adichie, and everyone enjoyed it immensely. Here are some review snippets from http://www.halfofayellowsun.com:


"We do not usually associate wisdom with beginners, but here is a new writer endowed with the gift of ancient storytellers. Chimamanda Ngozi Adichie knows what is at stake, and what to do about it. She is fearless, or she would not have taken on the intimidating horror of Nigeria's civil war. Adichie came almost fully made."
— Chinua Achebe


"Vividly written, thrumming with life, Chimamanda Ngozi Adichie's Half of a Yellow Sun is a remarkable novel. In its compassionate intelligence, as in its capacity for intimate portraiture, this novel is a worthy successor to such twentieth-century classics as Chinua Achebe's Things Fall Apart and V.S. Naipaul's A Bend in the River."
— Joyce Carol Oates


Author Chimamanda Adichie. Watch her TED talk here
“At once historical and eerily current, Half of a Yellow Sun takes place in the forests of southeastern Nigeria 40 years ago, and honors the memory of a war largely forgotten. Adichie’s prose thrums with life. Like Nadine Gordimer, Adichie position[s] her characters at crossroads where public and private allegiances threaten to collide. Half of a Yellow Sun [has] an empathetic tone that never succumbs to simplifying impulses, heroic or demonic . . . . Reaching deep, [it] speaks through history to our war-racked age not through abstract analogy but through the energy of vibrant detail, [and] a mastery of small things.”
—Rob Nixon, The New York Times Book Review

“Instantly enthralling . . . Vivid . . . Adichie weaves [her] characters into a finely wrought, inescapable web. The book sustains an intimate focus and an epic backdrop. Half of a Yellow Sun is not a conventional war story any more than is A Farewell to Arms or For Whom the Bell Tolls . . . . Powerful.”
—Janet Maslin, The New York Times


Meanwhile, back at the book club...

I’d have to say that my "women of the book club" are well-educated, professionals (mostly), well-read, and appreciate historical fiction as an easier-to-digest entree into politics, war, and social events that we know, sadly, that we haven’t heard enough about. We were into Indian work a few years back; now it’s more about Africa (we read Little Bee last year). The warm writing, the way that the author immerses us in worlds so different from our own and yet populates them with characters we can relate to…those are the gifts we seek in the fiction we read.

But somehow, as often happens when women meet to talk about books these days, the subject of Fifty Shades of Grey came up. I think it was when we moved to considering what we might like to read next, what we’d been reading recently…and one of our number (also recently treated for breast cancer—it’s a function of age, I know, but at some point, who can help not starting to view her own body as a traitorous walking time bomb?) segued into a book she tried but absolutely could NOT stand…and it was Fifty Shades of Grey.

Let’s see: it was poorly written, poorly plotted, the sex scenes weren’t in the least a turn on…and on and on it went. And so, off I went, once again defending it. It’s a fairy tale, a classic romance, I began. “The heroine is graduating university, she’s 23, and a virgin. Not only is she a virgin, she’s never even kissed a man.”

There was some general squawking: “Twenty-three and never even kissed anyone? In this day and age? Gimme a break…”

Yes, it’s a fairy tale. But, frankly, did anyone ever promise it was anything else?

So what makes Fifty Shades of Grey a compelling story, so much that 10 million American women bought it over six weeks earlier this year?

Well, here’s the way I tried, once again, to explain it:

--obviously, it’s partly the sex. But I don’t think it’s the BDSM as much as it is, to me, the notion of the forbidden, the envelope-pushing. How far from your personal comfort zone would you be willing to go to please your beloved? That, to me, is one of the essential hooks of the story, and EL James plays it like a pro.

--then, there’s the motherhood angle. Christian Grey is a damaged child. His backstory is ladled out in dribs and drabs. That is the other humungous hook: the damaged little boy that our heroine (us, in proxy) must connect with, and heal. Will she do it? Well, just in case we hadn’t noticed, it’s a friggin' romance (not to mention a romance about friggin')—which means HEA (happily ever after) is de rigueur.

--but here's the rub: everyone who hasn't read the book thinks it's Kate who is tasked with deciding how far she's willing to go to please her beloved. But those of us who actually READ the book(s) know that it's really Christian, after a decade of his depraved Dominant existence, who must decide if he's willing to give up his addiction to BDSM sex for the love of a good woman (who loves Austen novels, let us not forget, ergo a woman of quality…just like us. Women who wouldn’t be caught dead reading such laughably written smut…say what?). Again, the classic swoon-worthy love conquering all.

And that, perhaps, is the pleasure of reading something that, as a writer, I can recognize as derivative on so many levels. The dialogue, holy cow, is ludicrous. Ditto the star struck descriptions of Porsches and luxury villas, not to mention billionaire twenty-eight-year-olds. And the third act is so hokily ludicrous even I can't believe I read it (not to mention paid for it!).

Still and all, I enjoyed them.

In the Fifty Shades of Grey trilogy, readers are horses, and EL James rides us bareback, with sex and motherhood as the reigns. She pulls us this way and that as we gallop wildly along the bridlepath (bridalpath?). The thing is, the rider is really at the mercy of the horse, who is blind to this truth, or simply accepts it, deriving pleasure in serving her master.

Assuming the master, like EL James, knows just what she’s doing. And exactly where she’s taking us.

Friday, 21 September 2012

The Meaning of Children: Latest interview, at Inspiration Forum UK

From Inspiration Forum UK, September 2012

Thank you, Fiona McVie!

Those books aren't just going to read themselves, you know...
Our Interview with Beverly Akerman 
 
Name Beverly Akerman

Age North of 40, south of 60. Okay, you win: I’m 52.

Where are you from? Montreal, Quebec, Canada.

A little about your self ie. your education, family life, etc.
Born and raised in Montreal. In fact, I’ve never lived anywhere else. Sometimes I feel a bit bad about that, like it’s a character flaw or something. I have three kids well on their way to being grown-up. One moved out of the house to live on his own just this summer…and it was my middle guy, the one who’s always been easiest to get along with and the most helpful. (Or maybe it just seems that way; hindsight, rose coloured glasses and all that. Still, he was the only one of the three who used to point to his bed at night when we’d be rocking him in the rocking chair. He did like his sleep!) My husband is still here at home with me. I’m happy about that, actually. He worked in politics for many years, while our family was young. So I worked full-time, mostly, and single-parented it half the time.

I was busy and exhausted, so over-programmed that I don’t have all that many memories of that period. Why do we do this to ourselves? I suppose you’ve heard the saying, “Of course women can have it all: just not all at the same time.”

I have BSc and MSc degrees in biology from McGill University and worked for over 20 years in molecular genetics research. But I’d always known I’d be a writer some day. (At least, I’d always wanted/intended/hoped to be a writer some day…)

Fiona: Tell us your latest news?
I just had my longest ever giveaway on Amazon for the e-version of my award winning short story collection, The Meaning of Children, and it went really well. Over 4300 downloads, which I think is amazing for literary fiction. And the reviews—from periodicals as well as “real” readers-- are absolutely incredible as well. Words like “luminous,” “illuminated,” “haunting,” “a life-altering read,” “profound,” “a book of rare sensitivity and masterful creative writing”…You’d have to look on the Amazon.com book page to see them (it hasn’t quite caught on yet in the UK, I’m afraid) and on my blog.

Here are some links:
http://www.amazon.com/The-Meaning-of-Chi...B007H067R6
http://www.amazon.co.uk/The-Meaning-of-C...B007H067R6
http://beverlyakerman.blogspot.ca/p/rad-...aning.html

Fiona: When and why did you begin writing?
I'd always thought I'd be a writer some day. My first publication was a poem that won an honourable mention when I was nine and a half years old, something I wrote about in The Rampike last year, in the creative nonfiction piece "Aversion Conditioning, or Why I am Somewhat Conflicted About Poetry.” But I guess my imagination-my self confidence?-failed me because I could never seriously picture myself as a writer. So I put it aside, joked about needing to live life first in order to have something to write about (though maybe that isn't a joke), and tried to prove something (though exactly what and to whom I'm not quite sure) by distinguishing myself in math and science, the subjects everybody else seemed to think were the hardest.

I'd been keen on genetics since first learning about it in high school and in grade 10, when we were offered testing for Tay Sachs disease carrier status and one of my friends tested positive, I was well and duly hooked on DNA.

I majored in biology (human genetics) and went on to graduate work in genetics, where one of my most cherished delusions was that, once I finished the residency requirement and no longer paid by the credit, I'd be able to take all the English and creative writing courses I'd always dreamt of.

Guess how much time I had for non-science courses while pursuing a research degree in genetics?

That's right: none.

By 2003, I'd been in science for over two decades, mostly in McGill-affiliated labs. I'd been fairly successful, writing or co-writing 19 papers, mostly on mutations associated with several rare diseases. I also had a life--three kids and a husband who made a career in politics. But a funny thing happened as I waltzed through the genomes: the work had started to lose its meaning for me.

Something was wrong, I just couldn't put my finger on what, exactly.

And then my father-in-law, Gerry Copeman, died of lung cancer.

Gerry and I didn't even get along that well, although we'd made our peace, especially after the grandchildren arrived. But when he died, it affected me deeply, beyond the sadness of losing someone so close. For the first time, I understood-emotionally, as opposed to rationally or intellectually-that my time on this earth was finite, and that I'd better use it doing something I'd always dreamed of doing.

Which turned out to be, once I spent some time trying to figure it out, writing fiction.

So I switched gears, started taking writing workshops-the Quebec Writers' Federation has been stellar in providing learning opportunities for someone like me, unsure if she wanted to go back to university (and, more importantly, not convinced it would be helpful to have roomsful of young strangers tear up her work). I've been writing and submitting like mad ever since.

My first stories were published-online and in print-in 2006. Within a few years, I'd published more than 20 stories-in anthologies like the Aesthetica Creative Writing Annual 2012 and Best New Writing 2011, as well as literary journals and won or placed in a slew of contests. Links to my stories available online are on my blog. But let me direct you to a favourite of mine (and of my readers), “Pie.” It’s about love and loss, motherhood, baking, childrearing, and war.

And you can read it here:

http://beverlyakerman.blogspot.ca/2011/05/pie.html

Fiona: When did you first consider yourself a writer?
I’ve probably always considered myself a writer trapped in a non-writing body…but I remember when I won the Fog City Writers Fiction Contest…I opened the email and screamed. Hubby came running, thinking someone had died. But it was just that I’d won a $1,000 prize. I think that was the moment when I thought, “Okay, it’s not my imagination, this really is good work.” That was October 10th, 2007 (I had to look it up).

Fiona: How did you come up with the title?
I’d read somewhere that bestsellers were typically titled “The noun of noun” and so I played with that. The thing is, when I sat back and looked at the pile of stories I’d writing, the theme of children wasn’t hard to spot. I also realized, after submitting the collection for a while and getting nowhere with it (I am extremely impatient about such things) that I needed to have an overall structure to the book. So I thought about it some more and realized I could divide the book into “beginning”—stories from a child’s point of view—“middle”—about those in the child bearing years--and “end”—about older people, or stories that take the long view of life. And pretty soon after that, it was accepted for publication in Canada by Exile Editions.

Fiona: Is there a message in your story collection that you want readers to grasp?
You know, I think about that from time to time. There are 14 stories and I’d say that each of them has its own message and meaning, which may differ from reader to reader (and reading to reading). That’s what makes them literary, I guess.

I think one of the overall messages of the collection is about noticing those small moments of growth and insight, and that being a kid can be hard. Being a grown-up can be hard, too. And being a parent, a mother…well, let’s just say I wanted to shine the light on some feelings that are deep but not that much discussed. And they aren’t all dark, but some of them are.

Fiona: How much of the book is realistic?
Much of the book is quite realistic but I do have one story, “The Woman with Deadly Hands,” which, as you can tell from the title, is a bit of a fairy tale. But it’s a fairy tale for grown-ups. There’s sex in it, homosexuality, a deep dark secret, and a HEA ending (for happily ever after). Many of the themes, in fact, are similar to those in Fifty Shades of Grey, which is one of the reasons that trilogy appealed to me, though I don’t write soft porn. Probably more lucrative if I did!

Fiona: Are experiences based on someone you know, or events in your own life?
I tell everyone that the book is fiction. My kids always roll their eyes (or smirk, or both!) at that. So I’d have to also say some of the stories are based on real events in my own life, or those of people I know. But if real life is the basis of a story, I still take it and move it beyond the quotidian. Something has to happen to that interesting character, IMHO. Or it’s not really a story.

Fiona: What books have most influenced your life most?
As a writer? Mordecai Richler’s Barney’s Version is pretty much perfect, in my view. It’s largely about Montreal, it features characters brash and larger than life, it’s a book about the love of a man for his wife and children, it’s poignant and moving and very, very funny. A writer at the top of his game. If I could write something that had all that—humour, love of family, poignancy—I’d consider myself a success.
One of the things that means the most to me about it is that it’s about the love of a Jewish man for his Jewish wife…which is a kind of long story for me. Let’s just say that most male Jewish authors do not write about lovely and lovable Jewish women. If you like, you can read up on that here:
http://roverarts.com/2010/12/mordecai%E2%80%99s-women/
and here (because that was one of the few changes in the story when it was turned into film)
http://roverarts.com/2011/01/mordecai%E2...not-quite/

Other books that are important to me: Morley Callaghan’s The Loved and the Lost. I was very young when I read it and it impressed me immeasurably because it showed me my own home, Montreal, could be the setting for an important novel.
Then there’s the usual: Catcher in the Rye, To Kill a Mockingbird, both of which I re-read recently. The latter astounded me: these are books that are usually required reading for pre-teens here in Canada. So to discover that To Kill a Mockingbird was as much about parenting as about racism was a real eye-opener.

More recently, I’ve really enjoyed Lionel Shriver’s fearlessness in We Have to Talk About Kevin, and Michael Chabon’s tour de force The Amazing Adventures of Kavalier & Klay.

Fiona: If you had to choose, which writer would you consider a mentor?
I don’t think I could choose just one…there’s Colleen Curran, a playwright I’ve been studying with for the past few years. She is just incredibly motivating and supportive, and a wonderful all round bubbly person. She is a sucker for comedy and happily ever after (see her play Cake Walk or her novels, e.g. Something Drastic) but she has also written much more serious work (El Cladavista, Sacred Hearts).

Then there’s Neale McDevitt; I took writing workshops with him for about 18 months. He has a wonderful book of short fiction, One Day Even Trevi Will Crumble, quite a prescient title because I recently read that the fountain was out of commission for awhile after several chunks of it had broken away. Other writing teachers of who really stand out in my mind: Luis Alberto Urrea, and Nancy Zafris.

Fiona: What book are you reading now?
Right now I’m reading Half of a Yellow Sun by Chimamanda Ngozi Adichie for book club and really enjoying that.

Fiona: Are there any new authors that have grasped your interest?
All of them. Martin Crosbie, author of My Temporary Life, for example. Poet Samuel Peralta who is new to me, anyway. I’m learning so much on this indie experiment of mine.

Fiona: What are your current projects?
I’m still trying to figure out how to write a novel. I know how to start them, no problem. It’s keeping them going…that’s what I have to work on. I also have a couple of plays on the go.

Fiona: Name one entity that you feel supported you outside of family members.
Oh, there are many of those! An entire alphabet soup of initials: PWAC, for the Professional Writers Association of Canada, which helped me earn a (bit of? Modest?) living as a freelance writer; the QWF (Quebec Writers’ Federation), which made all the lovely writing workshops available for modest fees, the WFNB (Writers Federation of New Brunswick) for running the David Adams Richards Prize Contest, and; my Canadian publisher, Exile Editions.


Fiona: If you had to do it all over again, would you change anything in your latest book?
Yes: I wouldn’t have worried so much about no one wanting to publish it. I wouldn’t have said “yes” to the first offer; I would have investigated what a publisher was willing to do for me. I would have had more faith in my own talent.

Fiona: Do you have a blog/website? if so what is it?
http://beverlyakerman.blogspot.ca/


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Wednesday, 29 February 2012

Depression drugs may fight cancer (from the archives)


 

Groundbreaking McGill research yields compelling results

Could the black cloud of clinical depression have a silver lining? A recent study by McGill researchers shows that commonly prescribed anti-depressant medications known as Selective Serotonin Reuptake Inhibitors (SSRIs) may protect against developing colorectal cancer. The groundbreaking research was published in the April edition of the prestigious Lancet Oncology journal.


Previous work in mice demonstrated that SSRIs both retard the growth of transplanted human bowel tumours and make mice that are susceptible to developing colorectal cancer less likely to do so. "Serotonin has a stimulating effect on cell division and multiplication so [if] serotonin is a promoting factor, the logic for using antiserotonin drugs is strong," epidemiologist Jean-Paul Collet pointed out. "The strength of the study is that we started with a clear a priori hypothesis coming from animal studies. . . the question was to verify whether we would find the same type of association in human beings. What we found is that people with cancer had less use of SSRIs than the control subjects. This is why we think that SSRIs have a protective effect."


Jean-Paul Collet  
Photo: Claudio Calligaris


Russian doll syndrome

The study, funded by the U.S. National Institute of Health, was conducted with PhD student Wanning Xu and Professor Stanley Shapiro, a colleague of Collet's in the Department of Epidemiology and Biostatistics and Occupational Health, using the administrative databases of Saskatchewan Health and the Saskatchewan Cancer Agency registry. Although over 10,000 cancer patients and 40,000 age- and gender-matched controls were studied in the population-based, nested case-control study, it took Xu only about six months to perform the actual number-crunching.

There are some caveats to the results. "The study is large by number of patients but it is not an experimental study like a randomized clinical trial, [where] you administer a placebo or a true drug and follow patients prospectively. Randomized trials are the gold standard for evidence," Collet pointed out. Observational studies such as his can be biased by many uncontrolled factors. So in the conclusion, his Lancet paper notes "we support conducting more studies about this question and maybe studying SSRIs with high risk patients [who] because of genetic factors or polyposis would have a high risk of [developing] cancer. Another interesting population would be patients with cancer to see if SSRIs could prevent recurrence or metastasis."

Collet cautions that treating millions of people with SSRIs in the hope of preventing colorectal cancer in some hundreds of thousands would be a risky business. "This type of research is extremely useful to conduct more research to determine what is the real effect." Collet likens these studies to playing with nesting Russian babushka dolls: open one and there's almost always another one inside. He's confident there will be a definitive answer to the question of using SSRIs to prevent or treat colorectal cancer within 5 to 10 years, depending on international collaborative research networks and the attitude of the pharmaceutical companies involved.

Originally published in The McGill Reporter, March 30, 2006.